SOUTH CAROLINA — Officials in South Carolina are warning residents about a dangerous synthetic opioid known as cychlorphine that has recently been identified in the state.
Alan Wilson said the drug is often manufactured overseas, including in China, and trafficked into the United States by drug cartels.
Officials said cychlorphine is designed to be more potent, addictive and difficult to detect than other drugs. In many cases, it is mixed into other substances without a user’s knowledge, significantly increasing the risk of overdose.
According to the Tennessee Department of Health, more than 30 fatal overdoses linked to the drug have been reported statewide since October 2025, and it is believed to be about 10 times more potent than fentanyl.
Authorities said even trace amounts of the drug can be deadly and urged residents to avoid unknown or illicit substances, report suspicious activity and seek help for substance abuse when needed.
Law enforcement officials also cautioned first responders to use heightened care when handling potential exposures, as even incidental contact may pose serious health risks.
The warning comes as officials work to prevent further overdoses and protect communities across South Carolina.
